Sars-Cov-2 PCR

Background

During the peak of the COVID-19 pandemic in Kazakhstan (June 2020), the media reported multiple cases of SARS-CoV-2 PCR-negative pneumonia with increased mortality. Our objective was to study the epidemiological characteristics of hospitalized patients with positive and negative PCR with analysis of hospital and post-hospital mortality. We also compare the characteristics of respiratory diseases between 2019 and 2020.

Methods

The study population consists of 17,691 (March-July-2020) and 4,600 (March-July-2019) hospitalized patients with respiratory diseases (including COVID-19). Incidence rate, case fatality rate, and survival analysis for overall mortality (in-hospital and post-hospital) were evaluated.

  • Study population and data sources

The study population consisted of all hospitalized patients with respiratory illnesses (including COVID-19) according to the International Statistical Classification of Diseases and Related Health Problems (ICD-10) from March to July 2019 and from March to July 2020 in Turkestan oblast, Kazakhstan. The following ICD-10 codes were included in the study: J00-J06 (acute upper respiratory tract infections), J09-J18 (influenza and pneumonia), J20-J22 (other acute lower respiratory tract infections), J40- J47 (chronic diseases of the lower respiratory tract), J96-J99 (other diseases of the respiratory system), B34 (viral infection of unspecified site), Z20 (contact and “suspected” exposure to communicable diseases), U07.1 (COVID-19 specified virus) and U07 .2 (COVID-19 unspecified virus).

The raw data was retrieved from the Single National Electronic Health System (UNEHS) linked with the records to the “Electronic Registry of Internal Patients” that included data on dates of admission and discharge, ICD-10 codes, dates and results of PCR tests, discharge results and some demographic data. Global mortality statistics (in-hospital and post-hospital death) were obtained independently from the “Adjunct Population Registry” and were linked to hospitalized patients through the Population Registry Number (RPN-ID); each date of death followed by the date of hospital discharge is considered post-hospital mortality. The population census of the Turkestan oblast, including all cities and rural areas (2,016,100 people), was obtained from the State Statistics Committee.

  • SARS-CoV-2 infection detection method

Confirmation of SARS-CoV-2 infection was performed by real-time quantitative PCR on nasopharyngeal swabs with the BGI kit (Beijing Genomics Institute, Shenzhen, China) in defined special regional laboratory settings.

  • Assessment results

Incidence, mortality and lethality rates were evaluated. Incidence and mortality rates were calculated for each year using the number of newly diagnosed patients and deaths, and the size of the population. The case fatality rate was calculated by dividing the number of deaths by the number of newly diagnosed cases. The incidence was compared by year of admission. All-cause mortality was divided into in-hospital and post-hospital mortality, which was used to identify associated risk factors among admissions in 2020.

The start of follow-up was the date of hospital admission, and patients were followed until death or the end of the follow-up period (August 30, 2020). Two outcome variables were of interest for survival analysis: in-hospital mortality (time from hospital admission to hospital discharge) and overall (in-hospital and post-hospital combined) mortality (time from hospital admission to death at any time up to 30 days). August 2020). ). Censoring for in-hospital mortality survival analysis was taken on the date of hospital discharge, and for pooled mortality, it was August 30, 2020.

  • Statistic analysis

For each diagnostic group, absolute numbers of hospitalizations and deaths, incidence and mortality rates per 100,000, case fatality rates per year were reported. Absolute and relative frequencies were reported for categorical variables. Means and standard deviations were used to describe continuous variables, while biased continuous variables were characterized by medians and interquartile ranges (IQRs). Parametric bivariate analysis (Pearson’s Chi-squared, two-sample t-test, ANOVA) was used to assess associations of demographic and disease-related characteristics with outcome variables.

Kaplan-Meier survival curves were plotted for the results of the PCR test. Cox proportional hazards models were fitted with epidemiologically and statistically significant covariates using backwards stepwise selection. The proportional hazards assumption for different groups was tested using log plots. We performed a sensitivity analysis to assess the robustness of our main findings.

We examined the association between overall mortality (in-hospital and post-hospital) and sociodemographic parameters in a subgroup of patients admitted to only provisional and infectious disease hospitals (excluding patients who were in quarantine). The significance level of 5% (α < 0.05) was taken. All statistical analyzes were performed using STATA 16.0 statistical software. The study was approved by the Institutional Review Ethics Committee (NU-IREC 203/29112019) with exemption from informed consent.

Results

Respiratory disease incidence and mortality rates were 4 and 11 times higher in 2020 compared to 2019 (877.5 vs. 228.2 and 11.2 vs. 1.2 per 100,000, respectively). PCR-positive cases (compared to PCR-negative) had a two-fold increased risk of overall mortality. We observed a 24% higher risk of death in men than in women and in older patients than in younger ones. Patients residing in rural areas had a 66% higher risk of death compared to city residents, and being treated in a makeshift hospital was associated with 1.9 times higher mortality compared to those treated in hospitals of infectious diseases.

Conclusion

This is the first study from the Central Asia and Eurasia regions, assessing mortality from SARS-CoV-2 PCR positive and PCR negative respiratory system diseases during the peak of the COVID-19 pandemic. We describe a higher mortality rate for PCR-positive cases compared to PCR-negative cases, for men compared to women, for older patients compared to younger patients, and for patients living in rural areas. rural compared to city residents.

SARS-CoV-2 Spike Variant

Summary

Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome are expected to be deleterious and rapidly cleared or relatively neutral, a small proportion will affect functional properties and may alter infectivity. , the severity of disease, or interactions with the host. immunity. The appearance of SARS-CoV-2 in late 2019 was followed by a period of relative evolutionary stasis that lasted approximately 11 months.

However, since the end of 2020, the evolution of SARS-CoV-2 has been characterized by the appearance of sets of mutations, in the context of “variants of concern”, that affect the characteristics of the virus, including transmissibility and antigenicity, probably in response to the changing immune system profile of the human population. There is emerging evidence of reduced neutralization of some SARS-CoV-2 variants by post-vaccination serum; however, a greater understanding of the correlates of protection is required to assess how this may affect vaccine efficacy.

However, manufacturers are preparing platforms for a possible update of vaccine sequences, and it is critical that monitoring of genetic and antigenic changes in the global virus population be carried out alongside experiments to elucidate the phenotypic impacts of vaccines. mutations. In this review, we summarize the literature on mutations of the spike variant protein of SARS-CoV-2, the primary antigen, focusing on their impacts on antigenicity and contextualizing them in protein structure, and discussing them in the context of frequencies of mutation observed in the world sequence data sets.

SARS-CoV-2 spike variants

Sites of variation in the SARS-CoV-2 spike protein. Amino acids in bright red have variations in many individuals, pink amino acids vary in fewer individuals, and white amino acids show very few variants. Viruses, in their nonsensical way, are masters of evolution. Two aspects of viral biology make them particularly successful. First, huge populations of viruses are generated as they infect cells and replicate. For example, during the peak of SARS-CoV-2 infection, there may be between 1 and 100 billion viruses in an infected person.

Second, their molecular machinery for replication is often sloppy, introducing occasional errors into the progeny. This is the perfect combination for rapid evolution. During an infection, many variants of the virus can be produced in these populations. Most sequence variations will harm the virus or be neutral with little change for better or worse, but the occasional variant will improve some aspect of the viral life cycle. These rare advantageous variants have emerged several times in SARS-CoV-2 and have caused new waves of infection in the current COVID-19 pandemic.

Variation assessment

Scientists around the world have studied the evolution of SARS-CoV-2 to understand its capabilities and help plan for the future. The illustration shown here maps the main sites of variation of the spike protein, based on more than 3 million samples that have been sequenced and deposited in the GISAID database. The structure is based on PDB ID 7kj2, but the coordinates were taken from SWISS-MODEL since the original PDB entry does not have atomic coordinates for several flex loops. Also, glycosylation is not shown in this illustration, to make protein variation easier to see, so you should imagine the protein covered with multiple carbohydrate chains.

Functional improvements

As you can see, the variation sites are scattered throughout the three-dimensional structure. Scientists are still working out the functions of each of these changes, but some of the more common sites of variation are becoming clearer. The most common mutation (currently at least) is at position 614.

It is believed to control the stability of the top of the spike. Another common mutation, 681, is found in a flexible loop that is clipped by the cellular protease furin, breaking the chain into two pieces. The upper part (S1) recognizes the host cell and the lower part (S2) directs fusion and cell entry. Researchers have found that this cleavage makes the virus more infectious with cells in the respiratory tract.

Variant structures

During the COVID-19 pandemic, SARS-CoV-2 has spread throughout the world and variants have emerged by chance in different countries and spread rapidly from there. Recent variant structures (PDB IDs 7lwv, 7lyo, 7v7q, 7v7e, 7t9k). They all have multiple changes, including sites where an amino acid has mutated (shown in red) and sites where amino acids have been removed from the chain.

They all include the two common changes mentioned above, along with other changes scattered throughout the structure. These can benefit the virus in many ways: mutations in the receptor-binding domain and C-terminal domains can improve recognition and attachment to cells, changes in the N-terminal domain can help evade the immune system and mutations in the S2 region can enhance the process of fusion and cell entry.

Peak variation at position 614

Mutation from aspartate to glycine at position 614 (shown in red) removes an interaction with threonine 859 (turquoise) in a neighbouring subunit in the trimeric peak. This is thought to loosen the structure, facilitating the transition to the active conformation with extended receptor-binding domains. To compare the native structure with aspartate at position 614 (PDB ID 6vyb) and the variant delta-mutated structure with glycine (PDB ID 7v7q).

Nasopharyngeal Carcinoma

Overview

Nasopharyngeal carcinoma is a cancer that occurs in the nasopharynx, which is located behind the nose and above the back of the throat. Nasopharyngeal carcinoma is rare in the United States. It occurs much more frequently in other parts of the world, specifically in Southeast Asia.

Nasopharyngeal carcinoma is difficult to detect early. This is probably because the nasopharynx is not easy to examine and the symptoms of nasopharyngeal carcinoma are similar to other more common conditions. Treatment for nasopharyngeal carcinoma usually involves radiation therapy, chemotherapy, or a combination of the two. You can work with your doctor to determine the exact approach for your particular situation.

Symptoms

In its early stages, nasopharyngeal carcinoma may not cause any symptoms. Possible notable symptoms of nasopharyngeal carcinoma include:

  • A lump in the neck caused by a swollen lymph node
  • blood in your saliva
  • Bloody discharge from the nose
  • Nasal congestion or ringing in the ears
  • Hearing loss
  • Frequent ear infections
  • Throat pain
  • Headaches

When to see a doctor

Early symptoms of nasopharyngeal carcinoma may not always prompt you to see your doctor. However, if you notice unusual and persistent changes in your body that don’t seem right to you, such as unusual nasal congestion, see your doctor.

Causes

Cancer begins when one or more gene mutations cause normal cells to grow out of control, invade surrounding structures, and eventually spread (metastasize) to other parts of the body. In nasopharyngeal carcinomas, this process begins in the squamous cells that line the surface of the nasopharynx.

It is not known exactly what causes the genetic mutations that lead to nasopharyngeal carcinoma, although factors, such as the Epstein-Barr virus, have been identified that increase the risk of this cancer. However, it is not clear why some people with all risk factors never develop cancer, while others with no apparent risk factors do.

Risk factor’s

Researchers have identified some factors that seem to increase the risk of developing nasopharyngeal carcinoma, including:

  • Sex. Nasopharyngeal carcinoma is more common in men than in women.
  • Race. This type of cancer most commonly affects people in parts of China, Southeast Asia, and North Africa. In the United States, Asian immigrants have a higher risk of this type of cancer than Asians born in the United States. Alaskan Eskimos are also at increased risk of nasopharyngeal cancer.
  • Years. Nasopharyngeal cancer can occur at any age, but it is most often diagnosed in adults between the ages of 30 and 50.
  • Salt-cured foods. Chemicals released in the steam when cooking salt-cured foods, such as canned fish and vegetables, can enter the nasal cavity, increasing the risk of nasopharyngeal carcinoma. Being exposed to these chemicals at a young age can further increase the risk.
  • Epstein Barr virus. This common virus usually produces mild signs and symptoms, like those of a cold. It can sometimes cause infectious mononucleosis. The Epstein-Barr virus is also linked to several rare cancers, including nasopharyngeal carcinoma.
  • Family history. Having a relative with nasopharyngeal carcinoma increases the risk of developing the disease.
  • Alcohol and tobacco. Excessive alcohol consumption and tobacco use can increase the risk of developing nasopharyngeal carcinoma.

Complications

Complications of nasopharyngeal carcinoma can include:

  • Cancer that grows to invade nearby structures. Advanced nasopharyngeal carcinoma can cause complications if it grows large enough to invade nearby structures, such as the throat, bones, and brain.
  • Cancer has spread to other areas of the body. Nasopharyngeal carcinoma often spreads (metastasizes) beyond the nasopharynx.

Most people with nasopharyngeal carcinoma have regional metastases. This means that cancer cells from the original tumour have migrated to nearby areas, such as the lymph nodes in the neck. Cancer cells that spread to other areas of the body (distant metastases) most often travel to the bones, lungs, and liver.

Prevention

There is no sure way to prevent nasopharyngeal carcinoma. However, if you are concerned about your risk of nasopharyngeal carcinoma, you may want to consider avoiding habits that have been associated with the disease. For example, you can choose to reduce the amount of salt-cured foods you eat or avoid these foods altogether.

Tests to detect nasopharyngeal carcinoma

In the United States and other areas where the disease is rare, routine screening for nasopharyngeal carcinoma is not done. But in areas of the world where nasopharyngeal carcinoma is much more common—for example, in some areas of China—doctors may offer screening to people thought to be at high risk for the disease. Screening may include blood tests for the Epstein-Barr virus.

Prenatal Genetic Diagnosis of a Sex Chromosome Aneuploidy: Parent Experiences

Prenatal Genetic Diagnosis of a Sex Chromosome Aneuploidy: Parent Experiences
Sex chromosome aneuploidies (SCAs) happen in 1 in each 400 births. SCAs are extremely variable and have unsure prognoses, complicating the supply of prenatal cell-free DNA (cfDNA) outcomes or analysis following amniocentesis or chorionic villus sampling. Using a mixed-methods strategy, we explored the experiences of mother and father receiving a prenatal analysis of a fetus with SCA. Responses to open-ended questions had been qualitatively analyzed. Of the 323 mother and father who accomplished the survey, 122 obtained a prenatal analysis and answered no less than one open-ended query.
Most mother and father didn’t recall being knowledgeable that cfDNA screening or amniocentesis might reveal the presence of a SCA previous to testing and described feeling unprepared for a optimistic end result. Variation was discovered between mother and father who had been delivered a analysis by a genetic skilled versus different scientific specialties. Many mother and father expressed that the analysis was delivered in a means that emphasised the unfavorable attributes of the SCA and that they had been supplied restricted help supplies.
Parents who obtained a prenatal analysis of a SCA expressed a need for extra supportive supply of prenatal analysis that focuses on parental training and nuanced dialogue of potential phenotypes. Genetic counselors needs to be conscious of the vary of parental experiences when receiving a SCA analysis from non-genetic suppliers. Prenatal SCA diagnoses are predicted to extend as prenatal cfDNA screening turns into extra broadly used. Collaborations for higher supplier training and complete supplies on SCAs are important to facilitate the supply of SCA diagnoses and enhance guardian understanding and help.

Inference of inhabitants genetic parameters from an irregular time collection of seasonal influenza virus sequences

Basic abstract statistics that quantify the inhabitants genetic construction of influenza virus are essential for understanding and inferring the evolutionary and epidemiological processes. However, the sampling dates of international virus sequences within the final a number of a long time are scattered nonuniformly all through the calendar. Such temporal construction of samples and the small efficient measurement of viral inhabitants hampers the use of typical strategies to calculate abstract statistics.
Here, we outline statistics that overcome this downside by correcting for the sampling-time distinction in quantifying a pairwise sequence distinction. A easy linear regression technique collectively estimates the mutation price and the extent of sequence polymorphism, thus offering an estimate of the efficient inhabitants measurement. It additionally results in the definition of Wright’s FST for arbitrary time-series information. Furthermore, as a substitute for Tajima’s D statistic or the site-frequency spectrum, a mismatch distribution corrected for sampling-time variations could be obtained and in contrast between precise and simulated information.
Application of these strategies to seasonal influenza A/H3N2 viruses sampled between 1980 and 2017 and sequences simulated underneath the mannequin of recurrent optimistic choice with metapopulation dynamics allowed us to estimate the synonymous mutation price and discover parameter values for choice and demographic construction that match the remark. We discovered that the mutation charges of HA and PB1 segments earlier than 2007 had been notably excessive and that together with recurrent optimistic choice in our mannequin was important for the genealogical construction of the HA section. Methods developed right here could be typically utilized to inhabitants genetic inferences utilizing serially sampled genetic information.

Atypical Genetic Basis of Pyrazinamide Resistance in Mono-resistant Mycobacterium tuberculosis

Pyrazinamide (PZA) is a broadly used antitubercular chemotherapeutic. Typically, PZA resistance (PZA-R) emerges in M. tuberculosis strains with current resistance to isoniazid and rifampicin (MDR) and is conferred by loss-of-function pncA mutations that inhibit conversion to its energetic kind, Pyrazinoic acid (POA). PZA-R departing from this canonical situation is poorly understood. Here, we genotype pncA and purported various PZA-R genes (panD, rpsA, and clpC1) with long-read sequencing of nineteen phenotypically PZA mono-resistant isolates collected in Sweden and evaluate their phylogenetic and genomic traits to a giant set of MDR PZA-R (MDRPZA-R) isolates. We report the primary affiliation of ClpC1 mutations with PZA-R in scientific isolates, within the ClpC1 promoter (clpC1p -138) and N-terminal (ClpC1Val63Ala).
Mutations have emerged in each these areas underneath POA choice in vitro and ClpC1N-terminal has been implicated additional, by its POA-dependent efficacy in PanD proteolysis. ClpC1Val63Ala mutants spanned 4 Indo-oceanic sublineages. Indo-oceanic isolates invariably harbored ClpC1Val63Ala and had been starkly overrepresented (OR=22.2, p <0.00001) amongst PZA mono-resistant isolates (11/19) in comparison with MDRPZA-R isolates (5/80). The genetic foundation of Indo-oceanic isolates’ overrepresentation in PZA mono-resistant TB stays undetermined, however substantial circumstantial proof suggests ClpC1Val63Ala confers low-level PZA resistance. Our findings spotlight ClpC1 as doubtlessly clinically related for PZA-R and reinforce the significance of genetic background within the trajectory of resistance growth.

Exploring mother and father’ perceptions of the worth of pediatric genetic counseling affected person letters: A qualitative research presenting classes realized

Genetic counseling affected person letters are a helpful complement to genetic counseling follow. As the demand for genetic companies will increase, enhancing effectivity in each day duties resembling letter writing might enhance genetic counselor workflow. Additionally, understanding the worth recipients place on the content material of these letters previous to creating efficiencies is important towards making certain that the utility of these letters will not be misplaced. To higher perceive mother and father’ perceptions of the letter’s worth within the pediatric genetic counseling setting, we employed a qualitative design involving 13 mother and father of youngsters who obtained a affected person letter following their analysis.
Prenatal Genetic Diagnosis of a Sex Chromosome Aneuploidy: Parent Experiences
Parents participated in a semi-structured focus group, interview, or cellphone interview, and the info had been analyzed utilizing thematic evaluation. In addition to gathering perceptions of their kid’s letter, we sought to study preferences for letter size, formatting, and stage of element by asking for verbal and written suggestions on three totally different letter codecs created for a fictional affected person. We used self-determination concept (SDT) framework to create the pattern letters, which states that a person’s expertise of autonomy, competence, and relatedness can influence their capacity to interact in actions.

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Description: Extracted from Albizzia julibrissin Durazz.;Store the product in sealed, cool and dry condition

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TN3915-50mg 50mg Ask for price
Description: Echinatine N-oxide

Echinatine N-oxide

TN3915-5mg 5mg Ask for price
Description: Echinatine N-oxide

Echitovenidine

TN3918-10mg 10mg Ask for price
Description: Echitovenidine

Echitovenidine

TN3918-1g 1g Ask for price
Description: Echitovenidine

Echitovenidine

TN3918-1mg 1mg Ask for price
Description: Echitovenidine

Echitovenidine

TN3918-50mg 50mg Ask for price
Description: Echitovenidine

Echitovenidine

TN3918-5mg 5mg Ask for price
Description: Echitovenidine

Echitoveniline

TN3919-10mg 10mg Ask for price
Description: Echitoveniline

Echitoveniline

TN3919-1g 1g Ask for price
Description: Echitoveniline

Echitoveniline

TN3919-1mg 1mg Ask for price
Description: Echitoveniline

Echitoveniline

TN3919-50mg 50mg Ask for price
Description: Echitoveniline

Echitoveniline

TN3919-5mg 5mg Ask for price
Description: Echitoveniline

Echistatin, ?1 isoform

B5391-.1 100 ug
EUR 699.6

Pig Echinococcus ELISA Kit

abx055765-96tests 96 tests
EUR 801.6

Echinococcus IgG ELISA Kit

DEIA1095 96T
EUR 667.2
Description: For the qualitative determination of IgG class antibodies against Hydatid in serum.

Echinococcus IgM ELISA Kit

DEIA1096 96T
EUR 667.2
Description: For the qualitative determination of IgM class antibodies against Hydatid in serum.

Echinococcus IgG ELISA Kit

DEIA338 96T
EUR 618
Description: The Echinococcus IgG Antibody ELISA Test Kit has been designed for the the detection and the quantitative determination of specific IgG antibodies against Echinococcus in serum and plasma.

Echinoynethiophene A

TN2381-10mg 10mg Ask for price
Description: Echinoynethiophene A

Echinoynethiophene A

TN2381-1g 1g Ask for price
Description: Echinoynethiophene A

Echinoynethiophene A

TN2381-1mg 1mg Ask for price
Description: Echinoynethiophene A

Echinoynethiophene A

TN2381-50mg 50mg Ask for price
Description: Echinoynethiophene A

Echinoynethiophene A

TN2381-5mg 5mg Ask for price
Description: Echinoynethiophene A

Echinococcosis Antigen

E41H005 100ug
EUR 495

Canine echinococcus ELISA Kit

QY-E70197 96T
EUR 511.2

Echinococcus granulosus

BA107VS 30 mg
EUR 384

Porcine Echinococcus ELISA Kit

SL0245Po - Ask for price

ELISA kit for Human Echinococcus IgG  Kit

KTE62945-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Echinococcus IgG  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Echinococcus IgG  Kit

KTE62945-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Echinococcus IgG  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Echinococcus IgG  Kit

KTE62945-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Echinococcus IgG  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Echis carinatus Disintegrin EC3B

1-CSB-EP305526EAH
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Echis carinatus Disintegrin EC3B expressed in E.coli

Pig Echinococcus Antibody IgG ELISA Kit

abx055766-96tests 96 tests
EUR 801.6

Dog echinococcus antibody (IgG) ELISA kit

CSB-EQ027812DO-24T 1 plate of 24 wells
EUR 198
Description: Qualitative indirect ELISA kit for measuring Dog echinococcus antibody (IgG) in samples from serum. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Dog echinococcus antibody (IgG) ELISA kit

1-CSB-EQ027812DO
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Qualitative indirect ELISA kit for measuring Dog echinococcus antibody (IgG) in samples from serum. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Echinococcus Multilocularis

PCR-V103-PCRV10348D PCR-V103-48D
EUR 485

Echinococcus Multilocularis

PCR-V103-PCRV10396D PCR-V103-96D
EUR 685

Echinococcus Multilocularis

Oneq-V103-OneqV103100D Oneq-V103-100D
EUR 515

Echinococcus Multilocularis

Oneq-V103-OneqV103150D Oneq-V103-150D
EUR 594

Echinococcus Multilocularis

Oneq-V103-OneqV10350D Oneq-V103-50D
EUR 413

Dog echinococcus antibody (IgG) Elisa kit

EK762120 96 Wells
EUR 0.95

ELISA kit for Dog echinococcus antibody (IgG)

EK0055 96 tests
EUR 996
Description: Enzyme-linked immunosorbent assay kit for quantification of Dog echinococcus antibody (IgG) in samples from serum, plasma, tissue homogenates and other biological fluids.

Echinocystic acid (Albizziagenin)

T131553-10mg 10mg Ask for price
Description: Echinocystic acid (Albizziagenin)

Echinocystic acid (Albizziagenin)

T131553-1g 1g Ask for price
Description: Echinocystic acid (Albizziagenin)

Echinocystic acid (Albizziagenin)

T131553-1mg 1mg Ask for price
Description: Echinocystic acid (Albizziagenin)

Echinocystic acid (Albizziagenin)

T131553-50mg 50mg Ask for price
Description: Echinocystic acid (Albizziagenin)

Echinocystic acid (Albizziagenin)

T131553-5mg 5mg Ask for price
Description: Echinocystic acid (Albizziagenin)

Echinococcus Granulosus Antigen

NAT41602-100 0.1
EUR 391.66
Description: Echinococcus granulosus material is derived from bovine hydatid cyst as sterile filtered cyst fluid.

Echinococcus Granulosus Antigen

NAT41602-500 0.5
EUR 1176.24
Description: Echinococcus granulosus material is derived from bovine hydatid cyst as sterile filtered cyst fluid.

Human echinococcus antibody IgG ELISA Kit

201-12-1811 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Echinococcus Antibody IgG ELISA Kit

abx053454-96tests 96 tests
EUR 801.6

Human echinococcus antibody IgG ELISA Kit

CSB-E08976h-24T 1 plate of 24 wells
EUR 198
Description: Qualitative indirect ELISA kit for measuring Human echinococcus antibody IgG in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human echinococcus antibody IgG ELISA Kit

1-CSB-E08976h
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Qualitative indirect ELISA kit for measuring Human echinococcus antibody IgG in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Echinococcus Multilocularis PCR kit

PCR-V103-48D 50T
EUR 543.6

Echinococcus Multilocularis PCR kit

PCR-V103-96D 100T
EUR 686.4

Human echinococcus antibody IgG ELISA Kit

GA-E1827HM-48T 48T
EUR 346.8

Human echinococcus antibody IgG ELISA Kit

GA-E1827HM-96T 96T
EUR 559.2

Echinocystic acid 28-O-β-D-glucoside

T41139-10mg 10mg Ask for price
Description: Echinocystic acid 28-O-β-D-glucoside

Echinocystic acid 28-O-β-D-glucoside

T41139-1g 1g Ask for price
Description: Echinocystic acid 28-O-β-D-glucoside

Echinocystic acid 28-O-β-D-glucoside

T41139-1mg 1mg Ask for price
Description: Echinocystic acid 28-O-β-D-glucoside

Echinocystic acid 28-O-β-D-glucoside

T41139-50mg 50mg Ask for price
Description: Echinocystic acid 28-O-β-D-glucoside

Echinocystic acid 28-O-β-D-glucoside

T41139-5mg 5mg Ask for price
Description: Echinocystic acid 28-O-β-D-glucoside

Echinococcus Multilocularis RT PCR kit

RTq-V103-100D 100T
EUR 860.4

Echinococcus Multilocularis RT PCR kit

RTq-V103-150D 150T
EUR 969.6

Echinococcus Multilocularis RT PCR kit

RTq-V103-50D 50T
EUR 717.6

Human echinococcus antibody IgG ELISA Kit

QY-E04177 96T
EUR 472.8

Human echinococcus antibody IgG ELISA Kit

SL0638Hu 96 Tests
EUR 468

Human echinococcus antibody IgG Elisa Kit

EK700520 96 Wells
EUR 0.5

ELISA kit for Human echinococcus antibody IgG

EK0196 96 tests
EUR 996
Description: Enzyme-linked immunosorbent assay kit for quantification of Human echinococcus antibody IgG in samples from serum, plasma, tissue homogenates and other biological fluids.

Canine echinococcus Antibody IgG ELISA Kit

SL0056Ca - Ask for price

Echinocandin B Nucleus Hydrochloride

E081-10MG 10 mg
EUR 288.29
Description: C34H51N7O15 ∙ HCl

Human Echinococcus granulosus IgM ELISA Kit

QY-E05421 96T
EUR 433.2

Canine echinococcus granulosus (EG) ELISA Kit

SL0111Ca - Ask for price
This consists of caring for a baby with particular medical wants. While the findings from this work strengthened the significance of written communication for sufferers as seen in earlier analysis, this work uncovered three main themes in regards to the letter’s worth: (a) parts resembling readability and content material influence guardian emotions of autonomy and enhance competence shifting ahead with their kid’s care; (b) mother and father worth written acknowledgment of the emotional influence of the analysis; and (c) mother and father use the letter as a instrument to speak their kid’s analysis with others. These outcomes can be utilized for creating understandable affected person letters that help autonomy, competence, and relatedness.

Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing

Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing
Breast fibroepithelial lesions are biphasic tumors which comprise the frequent benign fibroadenomas (FAs) and the rarer phyllodes tumors (PTs). This examine analyzed 262 (42%) standard FAs, 45 (7%) mobile FAs, and 321 (51%) benign PTs contributed by the International Fibroepithelial Consortium, utilizing a beforehand curated 16 gene panel. Benign PTs have been discovered to own a better variety of mutations, and larger charges of most cancers driver gene alterations than each teams of FAs, specifically MED12, TERT promoter, RARA, FLNA, SETD2, RB1, and EGFR.
Cases with MED12 mutations have been additionally extra more likely to have TERT promoter, RARA, SETD2, and EGFR. There have been no vital differences detected between standard FAs and mobile FAs, apart from PIK3CA and MAP3K1. TERT promoter alterations have been most optimum in discriminating between FAs and benign PTs. Our examine affirms the function of sequencing and key mutations that will help in refining diagnoses of those lesions.

From allozymes to NGS: inhabitants genetics of forest bushes in Slovakia prior to now 40 years

This evaluation summarizes the event of inhabitants genetics and inhabitants genomics research of forest bushes in Slovakia in the course of the previous 40 years. Various protein and DNA markers have been utilized throughout this era to deal with a number of matters in evolutionary genetics and biogeography of bushes: allozymes, uniparentally inherited chloroplast and mitochondrial markers, easy sequence repeats and single nucleotide polymorphisms.
The principal object of research of phylogeny and postglacial migration have been Fagus sylvatica s.l. and eastern-Mediterranean firs (Abies Mill. part Abies), the place the divergence of genetic lineages (species and subspecific taxa) in time, in addition to colonization of the present ranges in the course of the Holocene have been reconstructed. The research on intraspecific gene movement and homoploid hybridization centered on hybrid swarms Pinus sylvestris/P. mugo and firs. Unusual maternal inheritance of chloroplast DNA was revealed in P. mugo × P. sylvestris crosses.
Contrasting geographical constructions of hybrid zones have been revealed in wind-dispersed vs. animal-dispersed bushes. Within the research of adaptation, alerts of choice have been recognized each in discipline observations and common-garden experiments on Picea abies, F. sylvatica and A. alba. Perspectives of ongoing analysis using next-generation sequencing have been shortly outlined.

Structural elements of rod opsin and their implication in genetic illnesses

Vision in dim-light situations is triggered by photoactivation of rhodopsin, the visible pigment of rod photoreceptor cells. Rhodopsin is manufactured from a protein, the G protein coupled receptor (GPCR) opsin, and the chromophore 11-cis-retinal. Vertebrate rod opsin is the GPCR finest characterised on the atomic stage of element.
Since the discharge of the primary crystal construction 20 years in the past, an enormous variety of constructions have been launched that, together with worthwhile spectroscopic determinations, unveiled most elements of the photobleaching course of. Numerous spontaneous mutations of rod opsin have been discovered linked to vision-impairing illnesses like autosomal dominant or autosomal recessive retinitis pigmentosa (adRP or arRP, respectively) and autosomal congenital stationary evening blindness (adCSNB). While adCSNB is especially attributable to constitutive activation of rod opsin, RP reveals extra variegate determinants affecting completely different elements of rod opsin operate.
The overwhelming majority of missense rod opsin mutations impacts folding and trafficking and is linked to adRP, an incurable illness that awaits gentle on its molecular construction determinants. This evaluation article summarizes all main structural info out there on vertebrate rod opsin conformational states and the insights gained up to now into the structural determinants of adCSNB and adRP linked to rod opsin mutations. Strategies to design small chaperones with therapeutic potential for chosen adRP rod opsin mutants will probably be mentioned as effectively.

Action detection utilizing a neural community elucidates the genetics of mouse grooming habits

Automated detection of complicated animal behaviors stays a difficult drawback in neuroscience, notably for behaviors that include disparate sequential motions. Grooming is a prototypical stereotyped habits and is commonly used as an endophenotype in psychiatric genetics. Here, we used mouse grooming habits for instance and developed a common function neural community structure able to dynamic motion detection at human observer-level efficiency and working throughout dozens of mouse strains with excessive visible variety.
We present insights into the quantity of human annotated coaching information which are wanted to attain such efficiency. We surveyed grooming habits within the open discipline in 2,457 mice throughout 62 strains, decided its heritable elements, carried out GWAS to stipulate its genetic structure, and carried out PheWAS to hyperlink human psychiatric traits through shared underlying genetics. Our common machine studying resolution that robotically classifies complicated behaviors in giant datasets will facilitate systematic research of behavioral mechanisms.
Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing

Shared genetic structure throughout psychiatric problems

Psychiatric problems overlap considerably on the genetic stage, with family-based strategies lengthy pointing towards transdiagnostic threat pathways. Psychiatric genomics has progressed quickly within the final decade, shedding gentle on the organic make-up of cross-disorder threat at a number of ranges of research. Over 100 genetic variants have been recognized that have an effect on a number of problems, with many extra to be uncovered as pattern sizes proceed to develop.
Cross-disorder mechanistic research construct on these findings to cluster transdiagnostic variants into significant classes, together with in what tissues or when in improvement these variants are expressed. At the upper-most stage, strategies have been developed to estimate the general shared genetic sign throughout pairs of traits (i.e. single-nucleotide polymorphism-based genetic correlations) and subsequently mannequin these relationships to determine overarching, genomic threat components.

AzuraQuant cDNA Synthesis Kit - 25 Reactions

AZ-1995 25 Reactions
EUR 183.6

Monkeypox Virus Real Time PCR Kit

PDPS-AR064 1 unit Ask for price
Description: Creative Biogene Monkeypox Virus Real Time PCR Kit is used for the detection of monkeypox Virus in serum or lesion exudate samples by using real time PCR systems. Monkeypox virus (MPV) is a double-stranded DNA, zoonotic virus and a species of the genus Orthopoxvirus in the family Poxviridae. It is one of the human orthopoxviruses that includes variola (VARV), cowpox (CPX), and vaccinia (VACV) viruses. The kit contains a specific ready-to-use system for the detection of the monkeypox Virus. Fluorescence is emitted and measured by the real time systems' optical unit during the PCR.

Monkeypox Virus Real Time PCR Kit

YJC70115NW-25T 25 tests/kit Ask for price
Description: The Bioperfectus Monkeypox Virus Real Time PCR Kit is an in vitro diagnostic test, based on real-time PCR technology, for the detection of DNA from the Monkeypox virus. Specimens can be obtained from human serum, lesion exudate samples and scab. BSL-2 facilities with standard BSL-2 work practices may be used for the test of t he Monkeypox virus.

Monkeypox Virus Real Time PCR Kit

ZD-0076-01 25 tests/kit Ask for price
Description: Monkeypox virus is the virus that causes the disease monkeypox in both humans and animals. Monkeypox virus is an Orthopoxvirus, a genus of the family Poxviridae that contains other viral species that target mammals. The virus is mainly found in tropical rainforest regions of central and West Africa. The primary route of infection is thought to be contact with the infected animals or their bodily fluids. The genome is not segmented and contains a single molecule of linear double-stranded DNA, 185000 nucleotides long. The Monkeypox Virus real time PCR Kit contains a specific ready-to-use system for the detection of the Monkeypox Virusthrough polymerase chain reaction (PCR) in the real-time PCR system. The master contains reagents and enzymes for the specific amplification of the Monkeypox Virus DNA. Fluorescence is emitted and measured by the real time systems ́ optical unit during the PCR. The detection of amplified Monkeypox Virus DNA fragment is performed in fluorimeter channel 530nm with the fluorescent quencher BHQ1. DNA extraction buffer is available in the kit and serum or lesion exudate samples are used for the extraction of the DNA. In addition, the kit contains a system to identify possible PCR inhibition by measuring the 560nm fluorescence of the internal control (IC). An external positive control defined as 1×10^7 copies/ml is supplied which allow the determination of the gene load.

Monkeypox Virus Real Time PCR Kit

ZD-0076-02 25 tests/kit Ask for price
Description: Monkeypox virus is the virus that causes the disease monkeypox in both humans and animals. Monkeypox virus is an Orthopoxvirus, a genus of the family Poxviridae that contains other viral species that target mammals. The virus is mainly found in tropical rainforest regions of central and West Africa. The primary route of infection is thought to be contact with the infected animals or their bodily fluids.The genome is not segmented and contains a single molecule of linear double-stranded DNA, 185000 nucleotides long.The Monkeypox Virus real time PCR Kit contains a specific ready-to-use system for the detection of the Monkeypox Virusthrough polymerase chain reaction (PCR) in the real-time PCR system. The master contains reagents and enzymes for the specific amplification of theMonkeypox VirusDNA. Fluorescence is emitted and measured by the real time systems ́ optical unit during the PCR. The detection of amplified Monkeypox Virus DNA fragment is performed in fluorimeter channelFAM with the fluorescent quencher BHQ1. DNA extraction buffer is available in the kit and serum or lesion exudate samples are used for the extraction of the DNA. In addition, the kit contains a system to identify possible PCR inhibition by measuring the HEX/VIC/JOE fluorescence of the internal control (IC). An external positive control defined as 1×107copies/ml is supplied which allow the determination of the gene load.

Human Pancreatic Cancer Primer Library

HPANC-I 1 set
EUR 657.6

0.2ML CLEAR STRIP CAPS FOR REAL TIME PCR

PCR-2CP-RT-C 125/pk
EUR 267.6
Description: PCR Plates & Tubes; PCR Strip Tubes and Strip Caps - Axygen

Azura PureView 1 Kb DNA Ladder - 100 Lanes

AZ-1101 100 Lanes
EUR 140.4

Azura PureView 1 Kb DNA Ladder - 500 Lanes

AZ-1105 500 Lanes
EUR 277.2

Azura PureView 1 Kb DNA Ladder - 1000 Lanes

AZ-1105-2 1000 Lanes
EUR 326.4

Azura PureView 250bp DNA Ladder - 100 Lanes

AZ-1121 100 Lanes
EUR 140.4

Azura PureView 250bp DNA Ladder - 500 Lanes

AZ-1125 500 Lanes
EUR 277.2

Azura PureView 250bp DNA Ladder - 1000 Lanes

AZ-1125-2 1000 Lanes
EUR 326.4

Azura PureView 100bp DNA Ladder - 100 Lanes

AZ-1131 100 Lanes
EUR 140.4

Azura PureView 100bp DNA Ladder - 500 Lanes

AZ-1135 500 Lanes
EUR 277.2

Azura PureView 100bp DNA Ladder - 1000 Lanes

AZ-1135-2 1000 Lanes
EUR 326.4

Azura PureView 50bp DNA Ladder - 100 Lanes

AZ-1151 100 Lanes
EUR 140.4

Azura PureView 50bp DNA Ladder - 500 Lanes

AZ-1155 500 Lanes
EUR 277.2

Azura PureView 50bp DNA Ladder - 1000 Lanes

AZ-1155-2 1000 Lanes
EUR 326.4

AzuraView GreenFast qPCR Blue Mix Lo Rox - 200 Rxn

AZ-2301 200 Rxn
EUR 214.8

AzuraView GreenFast qPCR Blue Mix Lo Rox - 500 Rxn

AZ-2305 500 Rxn
EUR 384

AzuraView GreenFast qPCR Blue Mix Lo Rox - 2000 Rxn

AZ-2320 2000 Rxn
EUR 1195.2

AzuraView GreenFast qPCR Blue Mix Lo Rox - 5000 Rxn

AZ-2325 5000 Rxn
EUR 2817.6

AzuraView GreenFast qPCR Blue Mix Hi Rox - 200 Rxn

AZ-2401 200 Rxn
EUR 214.8

AzuraView GreenFast qPCR Blue Mix Hi Rox - 500 Rxn

AZ-2405 500 Rxn
EUR 384

AzuraView GreenFast qPCR Blue Mix Hi Rox - 2000 Rxn

AZ-2420 2000 Rxn
EUR 1195.2

AzuraView GreenFast qPCR Blue Mix Hi Rox - 5000 Rxn

AZ-2421 5000 Rxn
EUR 2817.6

Mouse Gdnf Signaling Primer Library

MGDNF-I 1 set
EUR 657.6

Mouse Glucose Metabolism Primer Library

MGLM-I 1 set
EUR 657.6

Mouse Hippo Signaling Primer Library

MHPO-I 1 set
EUR 657.6

Mouse Hypoxia Signaling Primer Library

MHYP-I 1 set
EUR 657.6

Mouse Notch Signaling Primer Library

MNOT-I 1 set
EUR 657.6

Mouse Neurotransmitter Signaling Primer Library

MNTS-I 1 set
EUR 657.6

Mouse Integrin Signaling Primer Library

MINT-I 1 set
EUR 891.6

Mouse Oxidative Stress Primer Library

MOSL-I 1 set
EUR 657.6

Mouse Apoptosis Primer Library

MPA-I 1 set
EUR 540

Mouse Ras Signaling Primer Library

MRAS-I 1 set
EUR 657.6

Mouse T-Cell Receptor Signaling Primer Library

MTCR-I 1 set
EUR 657.6

Mouse TGF Beta Signaling Primer Library

MTGFB-I 1 set
EUR 657.6

Mouse Tumor Invasion/Metastasis Primer Library

MTIM-I 1 set
EUR 540

Mouse Tumor Immunity Primer Library

MTIMU-I 1 set
EUR 657.6

Mouse p53 Signaling Primer Library

MTPS-I 1 set
EUR 540

Mouse WNT Signaling Primer Library

MWNT-I 1 set
EUR 657.6

Mouse Toll-like Receptor Signaling Primer Library

newitem 1 set
EUR 657.6

Mouse PI3K-AKT Signaling Primer Library

MAKT-I 1 set
EUR 657.6

Mouse Angiogenesis Primer Library

MAPL-I 1 set
EUR 540

Mouse Adherin - Tight Junction Primer Library

MATJ-I 1 set
EUR 657.6

Mouse Autophagy Primer Library

MATPL-I 1 set
EUR 540

Mouse Bdnf Signaling Primer Library

MBDNF-I 1 set
EUR 657.6

Mouse BMP Signaling Primer Library

MBMP-I 1 set
EUR 657.6

Mouse Cytokine Primer Library I

MCA-I 1 set
EUR 540

Mouse Cytokine Primer Library II

MCA-II 1 set
EUR 540

Mouse Cell Cycle Primer Library

MCC-I 1 set
EUR 540

Mouse Cytokine and Chemokine Receptor Primer Library

MCCR-I 1 set
EUR 774

Mouse CREB Signaling Primer Library

MCREB-I 1 set
EUR 657.6

Mouse DNA Damage Signaling Primer Library

MDDS-I 1 set
EUR 657.6

Mouse DNA Repair Primer Library I

MDRL-I 1 set
EUR 774

Mouse DNA Repair Primer Library II

MDRL-II 1 set
EUR 774

Mouse Adipogenesis Primer Library

MADG-I 1 set
EUR 657.6

Mouse EGFR Signaling Primer Library

MEGFR-I 1 set
EUR 657.6

Mouse Epithelial-Mesenchymal Transition Primer Library

MEMT-I 1 set
EUR 657.6

Mouse Estrogen Receptor Signaling Library

MESR-I 1 set
EUR 774

Mouse Fatty Liver Signaling Primer Library

MFTL-I 1 set
EUR 657.6

Mouse Jak/Stat Signaling Primer Library

MJAK-I 1 set
EUR 774

Mouse MAP Kinase Signaling Primer Library

MMAP-I 1 set
EUR 657.6

Mouse Myeloid Derived Suppressor Cell Primer Library

MMDSC-I 1 set
EUR 657.6

Mouse NFKappaB Primer Library

MNFKB-I 1 set
EUR 540

Human DNA Repair Primer Library I

HDRL-I 1 set
EUR 657.6

Human DNA Repair Primer Library II

HDRL-II 1 set
EUR 657.6

Human Drug Transporter I Primer Library

HDTP-I 1 set
EUR 657.6

Human Drug Detoxication I

HDTX-I 1 set
EUR 657.6

Human Drug Detoxication II

HDTX-II 1 set
EUR 774

Human EGFR Signaling Primer Library

HEGFR-I 1 set
EUR 657.6

Human Epithelial Mesenchymal Transition Primer Library

HEMT-I 1 set
EUR 657.6

Human Endothelial Cell Primer Library

HEND-I 1 set
EUR 657.6

Human ERBB Signaling Primer Library

HERBB-I 1 set
EUR 657.6

Human Estrogen Signaling Primer Library

HESR-I 1 set
EUR 774

Human Focal Adhesion Signaling Primer Library

HFCA-I 1 set
EUR 657.6

Human FGF Receptor Signaling Primer Library

HFGF-I 1 set
EUR 774

Human Fatty Acid and Lipid Metabolism Primer Library

HFLM-I 1 set
EUR 657.6

Human Gastric Cancer Primer Library

HGCPL-I 1 set
EUR 657.6

Human GDNF Signaling Primer Library

HGDNF-I 1 set
EUR 657.6

Human Glucose Metabolism Primer Library

HGLM-I 1 set
EUR 540

Human G-Protein Coupled Receptor Signaling Primer Library

HGPCR-I 1 set
EUR 657.6

Human Hedgehog Signaling Primer Library

HHOG-I 1 set
EUR 774

Human Homeobox Gene Primer Library

HHOX-I 1 set
EUR 774

Human Hippo Signaling Primer Pathway

HHPO-I 1 set
EUR 657.6

Human Heat Shock Protein Primer Library

HHSP-I 1 set
EUR 891.6

Human Hypoxia Signaling Primer Library

HHYP-I 1 set
EUR 657.6

Human Interferon Type I Signaling Primer Library

HIFN-I 1 set
EUR 657.6

Human Interferon Type II Signaling Primer Library

HIFN-II 1 set
EUR 657.6

Human IL17 Signaling Primer Library

HIL17-I 1 set
EUR 657.6

Human Insulin Signaling Primer Library

HINS-I 1 set
EUR 657.6

Human Integrin Signaling Primer Library

HINT-I 1 set
EUR 657.6

Human Actin Cytoskeleton Signaling Primer Library

HACS-I 1 set
EUR 657.6

Human Adipogenesis Primer Library

HADG-I 1 set
EUR 657.6

Human Adaptive & Innate Immune Response Primer Library

HAIIR-I 1 set
EUR 657.6

Human PI3K-AKT Signaling Primer Library

HAKT-I 1 set
EUR 540

Human Amino Acid Metabolism Primer Library

HAMM-I 1 set
EUR 774

Human Androgen Signaling Primer Library

HAND-I 1 set
EUR 657.6

Human Angiogenesis Primer Library

HAPL-I 1 set
EUR 540

Human Antigen Processing and Presentation Primer Library

HAPP-I 1 set
EUR 657.6

Human Atherosclerosis Primer Library

HATH-I 1 set
EUR 657.6

Human Adherin - Tight Junction Primer Library

HATJ-I 1 set
EUR 657.6

Human Autophagy Primer Library

HATPL-I 1 set
EUR 540

Human Alzheimer's Disease Primer Library

HAZD-I 1 set
EUR 657.6

Human B-Cell Receptor Signaling Primer Library

HBCR-I 1 set
EUR 657.6

Human BDNF Signaling Primer Library

HBDNF-I 1 set
EUR 657.6

Human Bladder Cancer Primer Library

HBLCP-I 1 set
EUR 657.6

Human BMP Signaling Primer Library

HBMP-I 1 set
EUR 657.6

Human Brain Cancer Primer Library

HBRC-I 1 set
EUR 657.6
These components can subsequently be related to exterior traits (e.g. practical imaging phenotypes) to start to know the make-up of those transdiagnostic threat components. As psychiatric genomic efforts proceed to develop, we will start to realize even higher perception by together with extra fine-grained phenotypes (i.e. symptom-level information) and explicitly contemplating the atmosphere. The end result of those efforts will assist to tell bottom-up revisions of our present nosology.

The role of SAMM50 in non-alcoholic fatty liver disease: from genetics to mechanisms

The role of SAMM50 in non-alcoholic fatty liver disease: from genetics to mechanisms
Nonalcoholic fatty liver illness (NAFLD) is characterised by hepatic lipid accumulation. SAMM50 encodes Sam50, a mitochondrial outer membrane protein concerned in the elimination of reactive oxygen species, mitochondrial morphology, and regulation of mitophagy. Certain single nucleotide polymorphisms (SNPs) of SAMM50 have been reported to be correlated with NAFLD.
However, the contribution of SAMM50 polymorphisms to the prevalence and severity of fatty liver in the Chinese Han cohort has not often been reported. Here, we investigated the affiliation between SAMM50 polymorphisms (rs738491 and rs2073082) and NAFLD in a Chinese Han cohort, in addition to the mechanistic foundation of this affiliation. Clinical data and blood samples had been collected from 380 NAFLD instances and 380 regular topics for the detection of genotypes and biochemical parameters. Carriers of the rs738491 T-allele or rs2073082 G-allele of SAMM50 exhibit elevated susceptibility to NAFLD (OR=1.39; 95% CI=1.14-1.71, P=0.001; OR=1.31; 95% CI=1.05-1.62, P=0.016, respectively) and are correlated with elevated serum TG, ALT, and AST ranges.
The presence of the T allele (TT+CT) of rs738491 (P<0.01) or G allele (AG+GG) of rs2073082 (P=0.03) is correlated with the severity of fatty liver in the NAFLD cohort. In vitro research indicated that SAMM50 gene polymorphisms lower its expression and SAMM50 deficiency outcomes in elevated lipid accumulation due to a lower in fatty acid oxidation. Overexpression of SAMM50 enhances fatty acid oxidation and mitigates intracellular lipid accumulation. Our outcomes affirm the affiliation between the SAMM50 rs738491 and rs2073082 polymorphisms and the danger of fatty liver in a Chinese cohort. The underlying mechanism could also be associated to decreased fatty acid oxidation attributable to SAMM50 deficiency.

Cross-species transcriptomics uncovers genes underlying genetic lodging of developmental plasticity in spadefoot toads

That hardcoded genomes can manifest as plastic phenotypes responding to environmental perturbations is a captivating function of residing organisms. How such developmental plasticity is regulated on the molecular stage is starting to be uncovered aided by the event of -omic strategies. Here, we evaluate the transcriptome-wide responses of two species of spadefoot toads with differing capability for developmental acceleration of their larvae in the face of a shared environmental danger: pond drying.
By evaluating gene expression profiles over time and performing cross-species community analyses, we recognized orthologues and purposeful gene pathways whose environmental sensitivity in expression have diverged between species. Genes associated to lipid, ldl cholesterol and steroid biosynthesis and metabolism make up most of a module of genes environmentally responsive in one species, however canalized in the opposite. The evolutionary adjustments in the regulation of the genes recognized by means of these analyses might have been key in the genetic lodging of developmental plasticity in this technique.

Development of Host-Orthogonal Genetic Systems for Synthetic Biology

The building of a host-orthogonal genetic system can’t solely decrease the affect of host-specific nuances on fine-tuning of gene expression, but in addition broaden mobile features equivalent to in vivo steady evolution of genes based mostly on an error-prone DNA polymerase. It represents an rising highly effective strategy for making biology simpler to engineer.
In this evaluation, the latest advances are described on the design of genetic methods that may be stably inherited in the host cells and are answerable for necessary organic processes together with DNA replication, RNA transcription, protein translation, and gene regulation. Their functions in artificial biology are summarized and the longer term challenges and alternatives are mentioned in growing such methods.
The role of SAMM50 in non-alcoholic fatty liver disease: from genetics to mechanisms

Investigating the inhabitants construction and genetic variety of Arabian horses in Oman utilizing SNP markers

Arabian horses had been chosen for metabolic effectivity, magnificence, effectivity and endurance. Therefore, Bedouins have for hundreds of years traced their prized horses’ ancestries. With the institution of the World Arabian Horse Organization (WAHO), registration of Arabian horses grew to become centralized and international locations worldwide registered them in its database.
Most current Arabian horses in Oman right this moment had been imported after the 1970s and are predominantly flat-racing Arabians. This work geared toward revealing the genetic background and variety of Omani Arabian horses by evaluating them with Arabian horses from a various genetic background. To that finish, we genotyped 63 randomly sampled Arabian horses from Oman utilizing the Illumina Equine SNP70. For comparability, SNP genotypes of 12 Saudi Arabian horses, 27 French, 77 Egyptian, 11 Polish and 36 US Arabians had been included in the examine. We moreover included 17 Thoroughbred horses and 21 horses representing giant and small breeds as an outgroup. Our MDS evaluation and phylogenetic evaluation confirmed that the Arabian horses in Oman cluster primarily with French Arabian horses, with a number of horses clustering inside the Polish/US Arabians.
The French Arabian horse cluster was the closest to the Thoroughbred horses. Amongst the Arabian horses, plink common genomic inbreeding ranges had been highest in the Egyptian Arabian (0.169) adopted by the Saudi Arabian horses (0.137) and lowest in the Omani and French Arabian horses, -0.041 and -0.079 respectively. To our data, that is the primary report on the genetic background and variety of Arabian horses in Oman. Our outcomes demonstrated a particular subpopulation construction amongst Arabian horses and this data ought to advise future decision-making on Arabian horse breeding.

A generalized sturdy allele-based genetic affiliation check

The allele-based affiliation check, evaluating allele frequency distinction between case and management teams, is regionally strongest. However, utility of the classical allelic check is restricted in apply, as a result of the tactic is delicate to the Hardy-Weinberg equilibrium (HWE) assumption, not relevant to steady traits, and never straightforward to account for covariate impact or pattern correlation.
To develop a generalized sturdy allelic check, we suggest a brand new allele-based regression mannequin with particular person allele because the response variable. We present that the rating check statistic derived from this sturdy and unifying regression framework incorporates a correction issue that explicitly adjusts for potential departure from HWE, and encompasses the classical allelic check as a particular case.
When the trait of curiosity is steady, the corresponding allelic check evaluates a weighted distinction between individual-level allele frequency estimate and pattern estimate the place the load is proportional to a person’s trait worth, and the check stays legitimate beneath Y-dependent sampling. Finally, the proposed allele-based technique can analyze a number of (steady or binary) phenotypes concurrently and multi-allelic genetic markers, whereas accounting for covariate impact, pattern correlation and inhabitants heterogeneity. To assist our analytical findings, we offer empirical proof from each simulation and utility research. This article is protected by copyright. All rights reserved.

PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice

PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice
Recently, a number of genome-wide affiliation research recognized PHACTR1 as key locus for 5 numerous vascular issues: coronary artery disease, migraine, fibromuscular dysplasia, cervical artery dissection and hypertension. Although these signify important threat components or comorbidities for ischemic stroke, PHACTR1 function in mind small vessel ischemic disease and ischemic stroke most vital survival mechanism, such because the recruitment of mind collateral arteries like posterior speaking arteries (PcomAs), stays unknown.
Therefore, we utilized exome and genome sequencing in a multi-ethnic cohort of 180 early-onset unbiased familial and apparently sporadic mind small vessel ischemic disease and CADASIL-like Caucasian patients from US, Portugal, Finland, Serbia and Turkey and in 2 C57BL/6J stroke mouse fashions (bilateral widespread carotid artery stenosis [BCCAS] and center cerebral artery occlusion [MCAO]), characterised by totally different levels of PcomAs patency. We report three very uncommon coding variants in the small vessel ischemic disease-CADASIL-like cohort (p.Glu198Gln, p.Arg204Gly, p.Val251Leu) and a stop-gain mutation (p.Gln273*) in one MCAO mouse.
These coding variants do not cluster in PHACTR1 identified pathogenic domains and are not prone to play a critical function in small vessel ischemic disease or mind collateral circulation. We additionally exclude the chance that replicate quantity variants (CNVs) or a variant enrichment in Phactr1 could also be related to PcomA recruitment in BCCAS mice or linked to numerous vascular traits (cerebral blood move pre-surgery, PcomA measurement, leptomeningeal microcollateral size and junction density throughout mind hypoperfusion) in C57BL/6J mice, respectively.
Genetic variability in PHACTR1 is not prone to be a standard susceptibility issue influencing small vessel ischemic disease in patients and PcomA recruitment in C57BL/6J mice. Nonetheless, uncommon variants in PHACTR1 RPEL domains could affect the stroke final result and are price investigating in a bigger cohort of small vessel ischemic disease patients, totally different ischemic stroke subtypes and with purposeful research.

Insight of fetal to grownup hemoglobin change: Genetic modulators and therapeutic targets

The medical heterogeneity of β-hemoglobinopathies is so variable that it prompted the researchers to determine the genetic modulators of those ailments. Though the first modulator is the kind of β-globin mutation which impacts the diploma of β-globin chain synthesis, the co-inheritance of α-thalassemia and the fetal hemoglobin (HbF) ranges additionally act as potent secondary genetic modifiers.
As elevated HbF ranges ameliorate the severity of hemoglobinopathies, in this evaluate, the genetic modulators mendacity inside and outdoors the β-globin gene cluster with their believable function in governing the HbF ranges have been summarised, which in future could act as potential therapeutic targets.
PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice

Genetic affiliation of MMP14 promoter variants and their purposeful significance in gallbladder most cancers pathogenesis

Gallbladder most cancers (GBC) is comparatively uncommon however exhibits excessive frequency in sure geographical areas and ethnic teams, which embrace Northern and Eastern states of India. Previous research in India have indicated the doable function of genetic predisposition in GBC pathogenesis. Although matrix metalloproteinase-14 (MMP14) is identified modulator of tumour microenvironment and tumorigenesis and TCGA information additionally suggests its upregulation but, its function in genetic predisposition for GBC is utterly unknown.
We explored MMP14 promoter genetic variants as threat components and their implication in expression modulation and the pathogenesis of GBC. We genotyped all single nucleotide polymorphisms of MMP14 promoter by Sanger’s sequencing in roughly 300 GBC and 300 management examine topics of Indian ethnicity and, in 26 GBC tissue samples. Protein expression of MMP14 in GBC tissue samples was checked by immunohistochemistry. In vitro luciferase reporter assay was carried out to elucidate function of promoter genetic variants on expression ranges in two totally different cell traces.
MMP14 promoter variants, rs1003349 (p worth = 0.0008) and rs1004030 (p worth = 0.0001) have been considerably related to GBC. Luciferase reporter assay confirmed excessive expression for threat alleles of each the SNPs. Genotype-phenotype correlation for rs1003349 and rs1004030, in affected person pattern, confirmed that threat allele carriers had increased expression ranges of MMP14; furthermore, the correlation sample matched with genetic affiliation fashions. Overall, this examine unravels the affiliation of MMP14 promoter SNPs with GBC which contribute to pathogenesis by rising its expression.

Compact Genetic Algorithm-based Feature Selection for Sequence-based Prediction of Dengue-Human Protein Interactions

Dengue Virus (DENV) an infection is one of many quickly spreading mosquito-borne viral infections in people. Every yr, round 50 million folks get affected by DENV an infection, ensuing in 20,000 deaths. Despite the latest experiments specializing in dengue an infection to know its performance in the human physique, a number of functionally vital DENV-human protein-protein interactions (PPIs) have remained unrecognized. This article presents a mannequin for predicting new DENV-human PPIs by combining totally different sequence-based options of human and dengue proteins just like the amino acid composition, dipeptide composition, conjoint triad, pseudo amino acid composition, and pairwise sequence similarity between dengue and human proteins.
A Learning vector quantization (LVQ)-based Compact Genetic Algorithm (CGA) mannequin is proposed for characteristic subset choice. CGA is a probabilistic approach that simulates the habits of a Genetic Algorithm (GA) with lesser reminiscence and time necessities. Prediction of DENV-human PPIs is carried out by the weighted Random Forest approach because it is discovered to carry out higher than different classifiers. We have predicted 1013 PPIs between 335 human proteins and 10 dengue proteins.

CytoSelect 24-well Cell Migration Assay (8 ?m), Fluorometric

CBA-101-5 5 x 12 assays
EUR 2787.6
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines.

CytoSelect 96-well Cell Migration Assay (8 ?m), Fluorometric

CBA-106 96 assays
EUR 762
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines.

CytoSelect 96-well Cell Migration Assay (8 ?m), Fluorometric

CBA-106-5 5 x 96 assays
EUR 3135.6
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines.

CytoSelect IdU Competitive ELISA Kit

CBA-5100 96 assays
EUR 651.6

CytoSelect EdU Competitive ELISA Kit

CBA-5101 96 assays
EUR 651.6

CytoSelect BrdU Competitive ELISA Kit

CBA-5098 96 assays
EUR 651.6

CytoSelect Leukocyte Transmigration Assay

CBA-212 24 assays
EUR 888
Description: Cancer cell transmigration, particularly extravasation, is an important step in cancer metastasis. It is the final step in a cascade of interactions between cells and the endothelium. CytoSelect Leukocyte Transmigration Assay provides a robust system for the quantitative determination of transmigrations and interactions between endothelium and leukocytes. Migratory cells may be quantified on a fluorescence plate reader. Kits use 24-well plates with 3 µm pore size membrane inserts.

CytoSelect MTT Cell Proliferation Assay

CBA-252 960 assays
EUR 490.8
Description: Cell Biolabs? CytoSelect MTT Cell Proliferation Assay provides a colorimetric format for measuring and monitoring cell proliferation.  The kit contains sufficient reagents for the evaluation of 960 assays in 96-well plates or 192 assays in 24-well plates.  Cells can be plated and then treated with compounds or agents that affect proliferation.  Cells are then detected with the proliferation reagent, which is converted in live cells from the yellow tetrazole MTT to the purple formazan form by a cellular reductase (Figure 1).  An increase in cell proliferation is accompanied by an increased signal, while a decrease in cell proliferation (and signal) can indicate the toxic effects of compounds or suboptimal culture conditions.  The assay principles are basic and can be applied to most eukaryotic cell lines, including adherent and non-adherent cells and certain tissues.  This cell proliferation reagent can be used to detect proliferation in bacteria, yeast, fungi, protozoa as well as cultured mammalian and piscine cells.

CytoSelect 24-well Wound Healing Assay

CBA-120 24 assays
EUR 790.8
Description: Traditionally scratch assays have been used to study cell migration, cell proliferation and wound healing. However, these assays lack a consistently defined wound gap and can result in high inter-sample variation. Our CytoSelect 24-Well Wound Healing Assay provides a much more consistent method to measure cell migration across a wound field gap in vitro. Proprietary inserts generate a consistent 0.9mm wound gap between the cells. Cells may then be treated or monitored for proliferation or migration across the wound field by imaging samples at fixed time points or by time-lapse microscopy.

CytoSelect 24-well Wound Healing Assay

CBA-120-5 5 x 24 assays
EUR 3100.8
Description: Traditionally scratch assays have been used to study cell migration, cell proliferation and wound healing. However, these assays lack a consistently defined wound gap and can result in high inter-sample variation. Our CytoSelect 24-Well Wound Healing Assay provides a much more consistent method to measure cell migration across a wound field gap in vitro. Proprietary inserts generate a consistent 0.9mm wound gap between the cells. Cells may then be treated or monitored for proliferation or migration across the wound field by imaging samples at fixed time points or by time-lapse microscopy.

CytoSelect Tumor-endothelium Adhesion Assay

CBA-215 100 assays
EUR 692.4
Description: Leukocyte or tumor cell interactions with vascular endothelium consist of a cascade of processes including the firm attachment of cells to endothelial cell adhesion molecules. The CytoSelect Tumor Endothelium Adhesion Assay provides a robust system for the quantitative determination of interactions between tumor cells and endothelium. Adherent cells can be easily quantified on a fluorescence plate reader.

CytoSelect BrdU Cell Proliferation ELISA Kit

CBA-251 96 assays
EUR 637.2
Description: The CytoSelect BrdU Cell Proliferation ELISA Kit detects BrdU incorporated into cellular DNA during cell proliferation using an anti-BrdU antibody.  When cells are incubated in media containing BrdU, the pyrimidine analog is incorporated in place of thymidine into the newly synthesized DNA of proliferating cells.  Once the labeling media is removed, the cells are fixed and the DNA is denatured in one step with a fix/denature solution (denaturation of the DNA is necessary to improve the accessibility of the incorporated BrdU for detection).  Then an anti-BrdU mouse monoclonal antibody is added followed by an HRP conjugated secondary antibody to detect the incorporated BrdU.  The magnitude of the absorbance for the developed color is proportional to the quantity of BrdU incorporated into cells and can be directly correlated to cell proliferation.

CytoSelect Cell Viability and Cytotoxicity Assay

CBA-240 96 assays
EUR 470.4
Description: The CytoSelect Cell Viability and Cytotoxicity Assay Kit provides a simple format for monitoring cell viability via metabolic activity. Live cells are detected with either MTT (colorimetric detection) or Calcein AM (fluorometric detection). Dead cells are detected by EthD-1 reagent (fluorometric). All 3 detection reagents are included, along with Saponin (a cell death initiator). Prior to the assay, cells may be treated with compounds or agents that affect cell viability. This kit is suitable for eukaryotic cells, not yeast or bacteria.

CytoSelect 96-well Cell Transformation Assay

CBA-130 96 assays
EUR 866.4
Description: Our CytoSelect 96-Well Cell Transformation Assay (Soft Agar Colony Formation) is suitable for measuring cell transformation where no downstream analysis is required. Cells are incubated in a semisolid agar medium for 7-8 days. The cells are then solubilized, lysed and detected using the included fluorescent dye in a fluorometric plate reader.

CytoSelect 96-well Cell Transformation Assay

CBA-130-5 5 x 96 assays
EUR 3463.2
Description: Our CytoSelect 96-Well Cell Transformation Assay (Soft Agar Colony Formation) is suitable for measuring cell transformation where no downstream analysis is required. Cells are incubated in a semisolid agar medium for 7-8 days. The cells are then solubilized, lysed and detected using the included fluorescent dye in a fluorometric plate reader.

CytoSelect 24-Well Cell Co-Culture System

CBA-160 24 assays
EUR 525.6
Description: CytoSelect 24-Well Cell Co-Culture System provides a unique platform to monitor direct contact between two cell types in a single well. First, cells are cultured until they form a monolayer around the insert, creating a defined 8 mm cell-free zone. Once the insert is removed, a second cell type may be seeded into the exposed zone. The kit contains proprietary treated inserts and sufficient reagents for the evaluation of 24 samples. The inserts are compatible with most adherent cell types and experimental conditions.

CytoSelect 24-Well Cell Co-Culture System

CBA-160-5 5 x 24 assays
EUR 2078.4
Description: CytoSelect 24-Well Cell Co-Culture System provides a unique platform to monitor direct contact between two cell types in a single well. First, cells are cultured until they form a monolayer around the insert, creating a defined 8 mm cell-free zone. Once the insert is removed, a second cell type may be seeded into the exposed zone. The kit contains proprietary treated inserts and sufficient reagents for the evaluation of 24 samples. The inserts are compatible with most adherent cell types and experimental conditions.

CytoSelect 24-well Cell Invasion, Fluorometric

CBA-111 12 assays
EUR 714
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with ECM matrix gel (basement membrane), a protein mix isolated from EHS tumor cells.

CytoSelect 96-well Cell Invasion, Fluorometric

CBA-112 96 assays
EUR 908.4
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect 96-Well Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 96-well plates on a fluorescence plate reader. Inserts are precoated on the top of the membrane with Basement Membrane, an ECM protein mix isolated from EHS tumor cells.

CytoSelect 96-well Phagocytosis Assay (Zymosan)

CBA-224 96 assays
EUR 866.4
Description: Phagocytosis can be assayed by measuring the engulfment of a cell "substrate". However, traditional assays require tedious cell counting under a microscope. Our CytoSelect 96-Well Phagocytosis Assay, Zymosan Substrate provides a more accurate, user-friendly, high-throughput alternative to the standard phagocytosis assay. The assay may be adapted for use with 24-well or 48-well plates.

CytoSelect 96-well Phagocytosis Assay (Zymosan)

CBA-224-5 5 x 96 assays
EUR 3525.6
Description: Phagocytosis can be assayed by measuring the engulfment of a cell "substrate". However, traditional assays require tedious cell counting under a microscope. Our CytoSelect 96-Well Phagocytosis Assay, Zymosan Substrate provides a more accurate, user-friendly, high-throughput alternative to the standard phagocytosis assay. The assay may be adapted for use with 24-well or 48-well plates.

CytoSelect Tumor Transendothelial Migration Assay

CBA-216 24 assays
EUR 888
Description: Cancer cell transmigration, particularly extravasation, is an important step in cancer metastasis. It is the final step in a cascade of interactions between cells and the endothelium. CytoSelect Tumor Transendothelial Migration Assay provides a robust system for the quantitative determination of transmigrations and interactions between endothelium and tumor cells. Migratory cells may be quantified on a fluorescence plate reader. Kits use 24-well plates with 8 µm pore size membrane inserts.

CytoSelect 24-well Cell Haptotaxis Assay (8 µm), FN-coated, Colorimetric

CBA-100-FN 12 assays
EUR 679.2
Description: Cell haptotaxis describes cell migration toward or along a gradient of chemoattractants or adhesion sites in the extracellular matrix. The CytoSelect Cell Haptotaxis Assays are ideal for determining the migratory properties of cells. The 8 µm membrane pore size is ideal for epithelial cells and fibroblasts. The membrane serves as a barrier to distinguish between migratory and non-migratory cells.

CytoSelect 24-well Cell Haptotaxis Assay (8 µm), FN-coated, Fluorometric

CBA-101-FN 12 assays
EUR 714
Description: Cell haptotaxis describes cell migration toward or along a gradient of chemoattractants or adhesion sites in the extracellular matrix. The CytoSelect Cell Haptotaxis Assays are ideal for determining the migratory properties of cells. The 8 µm membrane pore size is ideal for epithelial cells and fibroblasts. The membrane serves as a barrier to distinguish between migratory and non-migratory cells.

CytoSelect 48-Well Cell Contraction Assay Kit

CBA-5021 48 assays
EUR 762
Description: Cell Biolabs? Cell Contraction Assays (Floating Matrix Model) provide a simple, in vitro system to assess cell contractivity and screen cell contraction mediators. The proprietary Cell Contraction Plate eliminates the matrix releasing step of the conventional contraction assay, providing a faster, higher-throughput method to assess cell contraction.

CytoSelect 384-well Cell Transformation Assay, Fluorometric

CBA-145 384 assays
EUR 1208.4
Description: Our CytoSelect 384-Well Cell Transformation Assay uses a modified soft agar 3D matrix to support the formation of colonies by neoplastic cells. Quantitation of cell transformation is performed on a fluorescence plate reader.

CytoSelect 384-well Cell Transformation Assay, Fluorometric

CBA-145-5 5 x 384 assays
EUR 4681.2
Description: Our CytoSelect 384-Well Cell Transformation Assay uses a modified soft agar 3D matrix to support the formation of colonies by neoplastic cells. Quantitation of cell transformation is performed on a fluorescence plate reader.

CytoSelect 24-well Cell Haptotaxis Assay (8 µm), COL-coated, Colorimetric

CBA-100-COL 12 assays
EUR 679.2
Description: Cell haptotaxis describes cell migration toward or along a gradient of chemoattractants or adhesion sites in the extracellular matrix. The CytoSelect Cell Haptotaxis Assays are ideal for determining the migratory properties of cells. The 8 µm membrane pore size is ideal for epithelial cells and fibroblasts. The membrane serves as a barrier to distinguish between migratory and non-migratory cells.

CytoSelect 24-well Cell Haptotaxis Assay (8 µm), COL-coated, Fluorometric

CBA-101-COL 12 assays
EUR 714
Description: Cell haptotaxis describes cell migration toward or along a gradient of chemoattractants or adhesion sites in the extracellular matrix. The CytoSelect Cell Haptotaxis Assays are ideal for determining the migratory properties of cells. The 8 µm membrane pore size is ideal for epithelial cells and fibroblasts. The membrane serves as a barrier to distinguish between migratory and non-migratory cells.

CytoSelect 24-Well Cell Migration Assay (8 µm, Colorimetric Format), Trial Size

CBA-100-T 4 assays
EUR 358.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines.

CytoSelect 24-Well Cell Migration Assay (8 µm, Fluorometric Format), Trial Size

CBA-101-T 4 assays
EUR 358.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 8 µm pore size is suitable for most cell types including epithelial cells, fibroblasts, and cancer cell lines.

CytoSelect 24-Well Wound Healing Assay, Trial Size

CBA-120-T 6 assays
EUR 428.4
Description: Traditionally scratch assays have been used to study cell migration, cell proliferation and wound healing. However, these assays lack a consistently defined wound gap and can result in high inter-sample variation. Our CytoSelect 24-Well Wound Healing Assay provides a much more consistent method to measure cell migration across a wound field gap in vitro. Proprietary inserts generate a consistent 0.9mm wound gap between the cells. Cells may then be treated or monitored for proliferation or migration across the wound field by imaging samples at fixed time points or by time-lapse microscopy.

CytoSelect 24-well Cell Invasion Assay, Colorimetric

CBA-110 12 assays
EUR 714
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with ECM matrix gel (basement membrane), a protein mix isolated from EHS tumor cells.

CytoSelect Cell Proliferation Assay Reagent (Fluorometric)

CBA-250 10 mL
EUR 490.8
Description: Cell Biolabs? CytoSelect Cell Proliferation Assay Reagent (Fluorometric) provides a fluorometric format for measuring and monitoring cell proliferation. Cells can be plated and then treated with compounds or agents that affect proliferation.  Cells are then incubated with the proliferation reagent.  Upon entering metabolically active live cells, the non-fluorescent proliferation reagent is converted into a bright red fluorescent form. An increase in cell proliferation is accompanied by increased fluorescent signal, while a decrease in cell proliferation (and signal) can indicate the toxic effects of compounds or suboptimal culture conditions.  The assay principles are basic and can be applied to most eukaryotic cell lines, including adherent and non-adherent cells and certain tissues.  This cell proliferation reagent can be used to detect proliferation in bacteria, yeast, fungi, protozoa as well as cultured mammalian and piscine cells. The kit contains sufficient reagents for the evaluation of 960 assays in ten 96-well plates or 192 assays in eight 24-well plates.

CytoSelect Cell Proliferation Assay Reagent (Colorimetric)

CBA-253 10 mL
EUR 490.8
Description: Cell Biolabs? CytoSelect WST-1 Cell Proliferation Assay Reagent provides a colorimetric format for measuring and monitoring cell proliferation.  The 10 mL volume is sufficient for the evaluation of 960 assays in ten 96-well plates or 192 assays in eight 24-well plates.  Cells can be plated and then treated with compounds or agents that affect proliferation.  Cells are then detected with the proliferation reagent, which is converted in live cells from WST-1 to the formazan form in the presence of cellular NADH and an electron mediator. An increase in cell proliferation is accompanied by increased signal, while a decrease in cell proliferation (and signal) can indicate the toxic effects of compounds or suboptimal culture conditions.  The assay principles are basic and can be applied to most eukaryotic cell lines, including adherent and non-adherent cells and certain tissues.  This cell proliferation reagent can be used to detect proliferation in bacteria, yeast, fungi, protozoa as well as cultured mammalian and piscine cells.

CytoSelect 96-well Phagocytosis Assay (Red Blood Cell)

CBA-220 96 assays
EUR 762
Description: Phagocytosis can be assayed by measuring the engulfment of a cell "substrate". However, traditional assays require tedious cell counting under a microscope. Our CytoSelect 96-Well Phagocytosis Assay, Red Blood Cell Substrate provides a more accurate, user-friendly, high-throughput alternative to the standard phagocytosis assay. The assay may be adapted for use with 24-well or 48-well plates.

CytoSelect 24-well Laminin Cell Invasion, Colorimetric

CBA-110-LN 12 assays
EUR 714
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with Laminin.

CytoSelect Clonogenic Tumor Cell Isolation Kit (5 preps)

CBA-155 5 preps
EUR 957.6
Description: Many solid tumors contain heterogeneous populations of normal and cancerous cells. Separation of these cell populations is key to an accurate assessment of the true genotypic and phenotypic differences between normal and tumor cells. Our CytoSelect Clonogenic Tumor Cell Isolation Kit uses a proprietary semisolid agar medium to facilitate formation of colonies by cells from solid tumors. Colonies are grown in either a 6-well plate or a 35mm culture dish. These colonies are isolated away from single (i.e. normal) cells by size filtration. The viable cells from these colonies can be easily recovered for further analysis.

CytoSelect 24-well Collagen Cell Invasion, Colorimetric

CBA-110-COL 12 assays
EUR 714
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with Collagen I.

CytoSelect 96-well Leukocyte-epithelium Adhesion Kit

CBA-211 100 assays
EUR 692.4
Description: Leukocyte or tumor cell interactions with vascular endothelium consist of a cascade of processes including the firm attachment of cells to endothelial cell adhesion molecules. The CytoSelect Leukocyte Epithelium Adhesion Assay provides a robust system for the quantitative determination of interactions between leukocytes and epithelium. Adherent cells can be easily quantified on a fluorescence plate reader.

CytoSelect 24-well Cell Migration and Invasion Assay (8 µm), Colorimetric, Combo Kit

CBA-100-C 2 x 12 assays
EUR 1166.4
Description: If you are assaying both invasive and migratory properties of your cells, order one of our economic CytoSelect Cell Migration  / Invasion Assay Combo kits. These kits save you money compared to buying separate chemotaxis and cell invasion kits. Each 24-well combo kit provides sufficient reagents to perform 12 cell migration plus 12 cell invasion assays.

CytoSelect 24-well Cell Migration and Invasion Assay (8 µm), Colorimetric, Combo Kit

CBA-100-C-5 10 x 12 assays
EUR 4771.2
Description: If you are assaying both invasive and migratory properties of your cells, order one of our economic CytoSelect Cell Migration  / Invasion Assay Combo kits. These kits save you money compared to buying separate chemotaxis and cell invasion kits. Each 24-well combo kit provides sufficient reagents to perform 12 cell migration plus 12 cell invasion assays.

CytoSelect 24-well Cell Migration and Invasion Assay (8 µm), Fluorometric, Combo Kit

CBA-101-C 2 x 12 assays
EUR 1166.4
Description: If you are assaying both invasive and migratory properties of your cells, order one of our economic CytoSelect Cell Migration  / Invasion Assay Combo kits. These kits save you money compared to buying separate chemotaxis and cell invasion kits. Each 24-well combo kit provides sufficient reagents to perform 12 cell migration plus 12 cell invasion assays.

CytoSelect 96-well Cell Migration and Invasion Assay (8 µm), Fluorometric, Combo Kit

CBA-106-C 2 x 96 assays
EUR 1375.2
Description: If you are assaying both invasive and migratory properties of your cells, order one of our economic CytoSelect Cell Migration  / Invasion Assay Combo kits. These kits save you money compared to buying separate chemotaxis and cell invasion kits. Each 96-well combo kit provides sufficient reagents to perform 96 cell migration plus 96 cell invasion assays.

CytoSelect 96-well Leukocyte-endothelium Adhesion Kit

CBA-210 100 assays
EUR 692.4
Description: Leukocyte or tumor cell interactions with vascular endothelium consist of a cascade of processes including the firm attachment of cells to endothelial cell adhesion molecules. The CytoSelect Endothelium Adhesion Assays provide a robust system for the quantitative determination of interactions between leukocytes or tumor cells and endothelium. Adherent cells can be easily quantified on a fluorescence plate reader.

CytoSelect 24-well Anoikis Assay (Colorimetric/Fluorometric)

CBA-080 24 assays
EUR 692.4
Description: Adhesion to the extraceullular matrix is essential for the survival and propagation of many adherent cells. Apoptosis resulting from the loss of adhesion to the ECM is known as anoikis. Anoikis is involved in the physiological processes of tissue renewal and cell homeostasis. Our CytoSelect Anoikis Assays allow you to quantify and monitor anoikis in cells using a precoated plate. Live cells can be viewed under a microscope and quantified on a plate reader by MTT (colorimetric) or Calcein AM (fluorometric); both reagents are included in the kit. Dead cells are detected with the red EthD-1 reagent, also included.

CytoSelect 96-well Anoikis Assay (Colorimetric/Fluorometric)

CBA-081 96 assays
EUR 727.2
Description: Adhesion to the extraceullular matrix is essential for the survival and propagation of many adherent cells. Apoptosis resulting from the loss of adhesion to the ECM is known as anoikis. Anoikis is involved in the physiological processes of tissue renewal and cell homeostasis. Our CytoSelect Anoikis Assays allow you to quantify and monitor anoikis in cells using a precoated plate. Live cells can be viewed under a microscope and quantified on a plate reader by MTT (colorimetric) or Calcein AM (fluorometric); both reagents are included in the kit. Dead cells are detected with the red EthD-1 reagent, also included.

CytoSelect Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit

CBA-254 96 assays
EUR 672
Description: Cell Biolabs? CytoSelect Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit is an enzyme immunoassay developed for the detection and quantitation of PCNA from nuclear and whole cell extracts.  The kit detects PCNA from mouse, rat and human, and has a detection sensitivity limit of 12.5 ng/mLPCNA.  Each kit provides sufficient reagents to perform up to 96 assays including standard curve and unknown samples. 

CytoSelect 24-well Cell Migration Assay (5 ?m), Fluorometric

CBA-102 12 assays
EUR 664.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

CytoSelect 24-well Cell Migration Assay (5 ?m), Fluorometric

CBA-102-5 5 x 12 assays
EUR 2787.6
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

CytoSelect 24-well Cell Migration Assay (3 ?m), Fluorometric

CBA-103 12 assays
EUR 664.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 3 µm pore size is best for the smallest cells including neutrophils and other leukocytes.

CytoSelect 24-well Cell Migration Assay (3 ?m), Fluorometric

CBA-103-5 5 x 12 assays
EUR 2787.6
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 3 µm pore size is best for the smallest cells including neutrophils and other leukocytes.

CytoSelect 96-well Cell Migration Assay (3 ?m), Fluorometric

CBA-104 96 assays
EUR 762
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 3 µm pore size is best for the smallest cells including neutrophils and other leukocytes.

CytoSelect 96-well Cell Migration Assay (3 ?m), Fluorometric

CBA-104-5 5 x 96 assays
EUR 3135.6
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 3 µm pore size is best for the smallest cells including neutrophils and other leukocytes.

CytoSelect 96-well Cell Migration Assay (5 ?m), Fluorometric

CBA-105 96 assays
EUR 762
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

CytoSelect 96-well Cell Migration Assay (5 ?m), Fluorometric

CBA-105-5 5 x 96 assays
EUR 3135.6
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

CytoSelect 24-well Cell Migration Assay (12 ?m), Colorimetric

CBA-107 12 assays
EUR 664.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their enviroment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 12 µm pore size is suitable for astrocytes and other large or slow-moving cells.

CytoSelect 24-well Cell Migration Assay (12 ?m), Fluorometric

CBA-108 12 assays
EUR 679.2
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their enviroment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 12 µm pore size is suitable for astrocytes and other large or slow-moving cells.

CytoSelect 48-well Cell Adhesion Assay (Laminin, Colorimetric)

CBA-056 48 assays
EUR 512.4
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Laminin.

CytoSelect 48-well Cell Adhesion Assay (Laminin, Fluorometric)

CBA-057 48 assays
EUR 553.2
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Laminin.

CytoSelect 24-well Laminin Cell Invasion Assay, Fluorometric

CBA-111-LN 12 assays
EUR 714
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with Laminin.

CytoSelect 96-well Laminin Cell Invasion Assay, Fluorometric

CBA-112-LN 96 assays
EUR 908.4
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect 96-Well Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 96-well plates on a fluorescence plate reader. Inserts are precoated on the top of the membrane with Laminin.

CytoSelect Clonogenic Tumor Cell Isolation Kit (5 x 5 preps)

CBA-155-5 25 preps
EUR 3894
Description: Many solid tumors contain heterogeneous populations of normal and cancerous cells. Separation of these cell populations is key to an accurate assessment of the true genotypic and phenotypic differences between normal and tumor cells. Our CytoSelect Clonogenic Tumor Cell Isolation Kit uses a proprietary semisolid agar medium to facilitate formation of colonies by cells from solid tumors. Colonies are grown in either a 6-well plate or a 35mm culture dish. These colonies are isolated away from single (i.e. normal) cells by size filtration. The viable cells from these colonies can be easily recovered for further analysis.

CytoSelect 24-well Collagen Cell Invasion Assay, Fluorometric

CBA-111-COL 12 assays
EUR 714
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with Collagen I.

CytoSelect 96-well Collagen Cell Invasion Assay, Fluorometric

CBA-112-COL 96 assays
EUR 908.4
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect 96-Well Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 96-well plates on a fluorescence plate reader. Inserts are precoated on the top of the membrane with Collagen I.

CytoSelect 48-well Cell Adhesion Assay (Fibrinogen, Colorimetric)

CBA-058 48 assays
EUR 512.4
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Fibrinogen.

CytoSelect 48-well Cell Adhesion Assay (Fibrinogen, Fluorometric)

CBA-059 48 assays
EUR 553.2
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Fibrinogen.

CytoSelect 48-well Cell Adhesion Assay (Fibronectin, Colorimetric)

CBA-050 48 assays
EUR 512.4
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Fibronectin.

CytoSelect 48-well Cell Adhesion Assay (Fibronectin, Fluorometric)

CBA-051 48 assays
EUR 553.2
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Fibronectin.

CytoSelect 48-well Cell Adhesion Assay (Collagen I, Colorimetric)

CBA-052 48 assays
EUR 512.4
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Collagen I.

CytoSelect 48-well Cell Adhesion Assay (Collagen I, Fluorometric)

CBA-053 48 assays
EUR 553.2
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Collagen I.

CytoSelect 48-well Cell Adhesion Assay (Collagen IV, Colorimetric)

CBA-060 48 assays
EUR 512.4
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Collagen IV.

CytoSelect 48-well Cell Adhesion Assay (Collagen IV, Fluorometric)

CBA-061 48 assays
EUR 553.2
Description: Cell adhesion is a complex process involved in migration/invasion, embryogenesis, wound healing and tissue remodeling. Cells adhere to the extracellular matrix, forming complexes with cytoskeleton components that can affect cell motility, differentiation, proliferation, and survival. Our CytoSelect 48-Well Cell Adhesion Assays provide a fully quantitative method for the evaluation of cell adhesion. The 48-well plate is precoated with Collagen IV.

CytoSelect 96-Well Phagocytosis Assay (E. coli, Colorimetric Format)

CBA-222 96 assays
EUR 831.6
Description: Phagocytosis can be assayed by measuring the engulfment of a cell "substrate". However, traditional assays require tedious cell counting under a microscope. Our CytoSelect 96-Well Phagocytosis Assay, E. coli Substrate provides a more accurate, user-friendly, high-throughput alternative to the standard phagocytosis assay. The assay may be adapted for use with 24-well or 48-well plates.

CytoSelect 96-Well Phagocytosis Assay(Zymosan Substrate), Trial Size

CBA-224-T 20 assays
EUR 463.2
Description: Phagocytosis can be assayed by measuring the engulfment of a cell "substrate". However, traditional assays require tedious cell counting under a microscope. Our CytoSelect 96-Well Phagocytosis Assay, Zymosan Substrate provides a more accurate, user-friendly, high-throughput alternative to the standard phagocytosis assay. The assay may be adapted for use with 24-well or 48-well plates.

CytoSelect 96-Well Hematopoietic Colony Forming Cell Assay (96 assays)

CBA-320 96 assays
EUR 644.4
Description: Hematopoietic stem cells (HSCs) are well-characterized, tissue-specific stem cells that are responsible for the lifelong maintenance of the hematopoietic system. HSCs or hematopoietic progenitors known as colony-forming cells (CFCs) proliferate to form discrete colonies when cultured in a suitable 3D environment, such as methylcellulose supplemented with nutrients and cytokines. Our CytoSelect 96-Well Hematopoietic Colony Forming Cell Assay promotes the formation of HSC colonies in just 7-10 days. Cells can then be either quantified in a fluorescence plate reader or recovered from the semisolid medium for further downstream analysis.

CytoSelect 24-Well Cell Contraction Assay Kit (Floating Matrix Model)

CBA-5020 24 assays
EUR 679.2
Description: Cell Biolabs? Cell Contraction Assays (Floating Matrix Model) provide a simple, in vitro system to assess cell contractivity and screen cell contraction mediators. The proprietary Cell Contraction Plate eliminates the matrix releasing step of the conventional contraction assay, providing a faster, higher-throughput method to assess cell contraction.

CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Colorimetric

CBA-135 96 assays
EUR 985.2
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis.

CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Colorimetric

CBA-135-5 5 x 96 assays
EUR 4027.2
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis.

CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Fluorometric

CBA-140 96 assays
EUR 1027.2
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis.

CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Fluorometric

CBA-140-5 5 x 96 assays
EUR 4179.6
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis.

CytoSelect 96-Well Hematopoietic Colony Forming Cell Assay (5 x 96 assays)

CBA-320-5 5 x 96 assays
EUR 2536.8
Description: Hematopoietic stem cells (HSCs) are well-characterized, tissue-specific stem cells that are responsible for the lifelong maintenance of the hematopoietic system. HSCs or hematopoietic progenitors known as colony-forming cells (CFCs) proliferate to form discrete colonies when cultured in a suitable 3D environment, such as methylcellulose supplemented with nutrients and cytokines. Our CytoSelect 96-Well Hematopoietic Colony Forming Cell Assay promotes the formation of HSC colonies in just 7-10 days. Cells can then be either quantified in a fluorescence plate reader or recovered from the semisolid medium for further downstream analysis.

CytoSelect 24-Well Cell Migration Assay (5 µm, Fluorometric Format), Trial Size

CBA-102-T 4 assays
EUR 358.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

CytoSelect 24-Well Cell Migration Assay (3 µm, Fluorometric Format), Trial Size

CBA-103-T 4 assays
EUR 358.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 3 µm pore size is best for the smallest cells including neutrophils and other leukocytes.

CytoSelect 96-well In Vitro Tumor Sensitivity Assay (Soft Agar Colony Formation)

CBA-150 96 assays
EUR 922.8
Description: Traditionally, the soft agar colony formation assay has been used to monitor anchorage-independent growth. Cells proliferate for 3-4 weeks in a semisolid culture medium, followed by tedious manual counting of colonies. Our CytoSelect 96-Well In Vitro Tumor Sensitivity Assay provides a stringent, anchorage-independent model for chemosenstivity testing and screening of potential anticancer drugs. After just 6-8 days, cell colonies are quantified using a standard colorimetric microplate reader.

CytoSelect 96-well In Vitro Tumor Sensitivity Assay (Soft Agar Colony Formation)

CBA-150-5 5 x 96 assays
EUR 3811.2
Description: Traditionally, the soft agar colony formation assay has been used to monitor anchorage-independent growth. Cells proliferate for 3-4 weeks in a semisolid culture medium, followed by tedious manual counting of colonies. Our CytoSelect 96-Well In Vitro Tumor Sensitivity Assay provides a stringent, anchorage-independent model for chemosenstivity testing and screening of potential anticancer drugs. After just 6-8 days, cell colonies are quantified using a standard colorimetric microplate reader.

CytoSelect 96-Well Cell Transformation Assay (Soft Agar Colony Formation), Trial Size

CBA-130-T 24 assays
EUR 463.2
Description: Our CytoSelect 96-Well Cell Transformation Assay (Soft Agar Colony Formation) is suitable for measuring cell transformation where no downstream analysis is required. Cells are incubated in a semisolid agar medium for 7-8 days. The cells are then solubilized, lysed and detected using the included fluorescent dye in a fluorometric plate reader.

CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Colorimetric, Trial Size

CBA-135-T 24 assays
EUR 518.4
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis.

CytoSelect 24-Well Cell Invasion Assay (Basement Membrane, Colorimetric Format), Trial Size

CBA-110-T 4 assays
EUR 386.4
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with ECM matrix gel (basement membrane), a protein mix isolated from EHS tumor cells.

CytoSelect 24-Well Cell Invasion Assay (Basement Membrane, Fluorometric Format), Trial Size

CBA-111-T 4 assays
EUR 386.4
Description: The ability of malignant tumor cells to invade normal surrounding tissue contributes in large part to the morbidity and mortality of cancers. Cell invasion requires several distinct cellular functions including adhesion, motility, detachment, and extracellular matrix proteolysis. Our CytoSelect Cell Invasion Assays utilize precoated inserts to assay the invasive properties of tumor cells. Invasive cells can be quantified in 24-well plates on either a standard microplate reader or a fluorescence plate reader. Inserts are precoated on the top of the membrane with ECM matrix gel (basement membrane), a protein mix isolated from EHS tumor cells.

CytoSelect 96-Well In Vitro Tumor Sensitivity Assay (Soft Agar Colony Formation), Trial Size

CBA-150-T 24 assays
EUR 483.6
Description: Traditionally, the soft agar colony formation assay has been used to monitor anchorage-independent growth. Cells proliferate for 3-4 weeks in a semisolid culture medium, followed by tedious manual counting of colonies. Our CytoSelect 96-Well In Vitro Tumor Sensitivity Assay provides a stringent, anchorage-independent model for chemosenstivity testing and screening of potential anticancer drugs. After just 6-8 days, cell colonies are quantified using a standard colorimetric microplate reader.

CytoSelect 96-Well Cell Transformation Assay (Cell Recovery Compatible, Fluorometric), Trial Size

CBA-140-T 24 assays
EUR 547.2
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis.

ELISA Microplate Washer Head (8 channel) replacement

MPW-WH-1 1
EUR 424.8

Poseidon™ 8 Channel Pipettor P10

33-GSC-8P10 1 Pipettor/Unit
EUR 383.64
Description: Adjustable Volume, 0.5 - 10µl

Poseidon™ 8 Channel Pipettor P20

33-GSC-8P20 1 Pipettor/Unit
EUR 383.64
Description: Adjustable Volume, 2 - 20µl

Poseidon™ 8 Channel Pipettor P200

33-GSC-8P200 1 Pipettor/Unit
EUR 383.64
Description: Adjustable Volume, 20 - 200µl

Poseidon™ 8 Channel Pipettor P300

33-GSC-8P300 1 Pipettor/Unit
EUR 383.64
Description: Adjustable Volume, 20 - 300µl

8-Channel Manifold for Accuris SmartWasher 96 Microplate Washer

MIC9604 EACH
EUR 446.4

ProPette™ LE 8 -Channel Pipette, 1 to 10µL

P5208-10U 1
EUR 399

ProPette™ LE 8 -Channel Pipette, 20 to 200µL

P5208-200U 1
EUR 399

ProPette™ LE 8 -Channel Pipette, 2 to 20µL

P5208-20U 1
EUR 399

ProPette™ LE 8 -Channel Pipette, 30 to 300µL

P5208-300U 1
EUR 399

ProPette™ LE 8 -Channel Pipette, 5 to 50µL

P5208-50U 1
EUR 399

8-Channel manifold

MW9600-8CM 1 each
EUR 337.6

Brand 8 Channel Manifold

BR704526-1EA EACH
EUR 15.02

ELISA Microplate Reader (compact, 8 channel, automated, programmable) with 4 filters & ELISA reader software

MPR-404 1
EUR 6637.2

ELISA Microplate Reader (compact, 8 channel, automated, programmable) with 6 filters & ELISA reader software

MPR-406 1
EUR 7075.2

8-channel reagent reservoir

DD316010 PK100
EUR 323.76

Tacta Pipette 8 Channel 5-100ul

PIP9730 EACH
EUR 999.6

Tacta Pipette 8 Channel 30-300ul

PIP9732 EACH
EUR 999.6

0.5-10uL Lambda 8-Channel

PIP0308 EACH
EUR 637.2

5-50uL Lambda 8-Channel

PIP0346 EACH
EUR 637.2

20-200uL Lambda 8-Channel

PIP0348 EACH
EUR 637.2

30-300uL Lambda 8-Channel

PIP0352 EACH
EUR 651.6

Tacta Pipette 8 Channel 0.5-10ul

PIP9728 EACH
EUR 999.6

Eppendorf Xplorer 8 Channel 50-1200ul

E4861000163 EACH
EUR 857.53

12-Channel Manifold for Accuris SmartWasher 96 Microplate Washer

MIC9602 EACH
EUR 492

Eppendorf Xplorer 8 Channel 0.5-10ul

E4861000104 EACH
EUR 857.53

PIPETTOR,8 CHANNEL,20-200UL,1 EA

4888 1/pk
EUR 1018.8
Description: Corning Liquid Handling Equipment; Costar 8 Pette and 12 Pette Multichannel Pipettors

Xplorer plus 8-channel 50-1200ul green

E4861000821 EACH
EUR 1033.46

Xplorer plus 8-channel 5-100ul yellow

E4861000783 EACH
EUR 1033.46

Xplorer plus 8-channel 15-300ul orange

E4861000805 EACH
EUR 1033.46
All predicted interactions are validated by literature filtering, GO-based evaluation, and KEGG Pathway enrichment evaluation. This examine will encourage the identification of potential targets for simpler anti-dengue drug discovery.

Functional characterisation of metal(loid) processes in planta through the integration of synchrotron techniques and plant molecular biology.

Functional characterisation of metal(loid) processes in planta through the integration of synchrotron techniques and plant molecular biology.

Functional characterisation of the genes regulating steel(loid) homeostasis in vegetation is a significant focus for phytoremediation, crop biofortification and meals safety analysis. Recent advances in X-ray focussing optics and fluorescence detection have tremendously improved the potential to make use of synchrotron techniques in plant science analysis.

With use of strategies resembling micro X-ray fluorescence mapping, micro computed tomography and micro X-ray absorption close to edge spectroscopy, steel(loids) might be imaged in vivo in hydrated plant tissues at submicron decision, and laterally resolved steel(loid) speciation can be decided beneath physiologically related circumstances.

This article focuses on the advantages of combining molecular biology and synchrotron-based techniques. By utilizing molecular techniques to probe the location of gene expression and protein manufacturing in mixture with laterally resolved synchrotron techniques, one can successfully and effectively assign practical info to particular genes.

A evaluation of the state of the artwork in this area is introduced, along with examples as to how synchrotron-based strategies might be mixed with molecular techniques to facilitate practical characterisation of genes in planta.

The article concludes with a abstract of the technical challenges nonetheless remaining for synchrotron-based laborious X-ray plant science analysis, notably these referring to subcellular stage analysis.

Functional characterisation of metal(loid) processes in planta through the integration of synchrotron techniques and plant molecular biology.
Functional characterisation of steel(loid) processes in planta through the integration of synchrotron techniques and plant molecular biology.

Population biology of fungal plant pathogens.

Studies of the inhabitants genetics of fungal and oomycetous phytopathogens are important to clarifying the illness epidemiology and devising administration methods.

Factors generally related to larger organisms resembling migration, pure choice, or recombination, are essential for the constructing of a clearer image of the pathogen in the panorama. In this chapter, we give attention to a restricted quantity of experimental and analytical strategies which are generally utilized in inhabitants genetics.

At first, we current differing kinds of qualitative and quantitative traits that might be recognized morphologically (phenotype). Subsequently, we describe a number of molecular strategies primarily based on dominant and codominant markers, and we offer our evaluation of the benefits and shortfalls of these strategies.

Third, we focus on numerous analytical strategies, which embody phylogenies, abstract statistics in addition to coalescent-based strategies, and we elaborate on the advantages related to every strategy. Last, we develop a case research in which we examine the inhabitants construction of the fungal phytopathogen Verticillium dahliae in coastal California, and assess the hypotheses of transcontinental gene move and recombination in a fungus that’s described as asexual.